Schulman 1986.

Methods	Allocation: random Single blind Exclusions after randomisation: 2 Losses to follow‐up: nil
Participants	Country: Sweden Participants: 38 Age: 26 to 74 years Sex: Male and female Inclusion criteria: venographically confirmed calf vein thrombosis duration < 7 days Exclusion criteria: previous thrombosis same leg; contraindication to thrombolysis
Interventions	Treatment: streptokinase 50,000 IU IV over 15 minutes then 100,000 IU over 12 hours for up to 7 days, titrated. Given with 5000 IU heparin IV over 12 hours. Warfarin begun after streptokinase ended Control: heparin 5000 IU IV bolus then 30,000 IU per day, titrated for 7 days. Warfarin begun simultaneously Co‐treatment: paracetamol, hydrocortisone or moduretic if necessary. 24 hours bed rest. Warfarin given for 5 to 6 months. Leg elevation. Elastic bandages. Elastic stockings where swelling or venous insufficiency detected at discharge or follow‐up
Outcomes	1 week: bleeding; clot lysis (venographic score); mortality; stroke; PE 1 month: clot lysis 1 year: clot lysis Up to 5 years: post‐thrombotic syndrome; foot volumetry
Notes	Low dose streptokinase. 2 patients excluded after randomisation, as they had previous thromboses
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"randomised, prospective study" but no further details given
Allocation concealment (selection bias)	Low risk	"allocated using sealed envelopes"
Blinding of participants and personnel (performance bias) All outcomes	Low risk	not possible due to the nature of the interventions but judged low risk as outcome assessment well described
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"..venograms were evaluated blindly in retrospect by one and the same radiologist"
Incomplete outcome data (attrition bias) All outcomes	Low risk	no missing data
Selective reporting (reporting bias)	Low risk	all outcomes reported
Other bias	Low risk	none