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Comparison of IC50 Values between ALK and INSR.
| IC50 (nM) | Ceritinib | Crizotinib | Alectinib |
|---|---|---|---|
| ALK | 0.2 | 3.0 | 1.9 |
| INSR | 7.0 | 290.0 | 550.0 |
| INSR IC50/ALK IC50 | 46.7 | 96.7 | 289.5 |
ALK: anaplastic lymphoma kinase, INSR: insulin receptor
Data of ceritinib and crizotinib was referred to the prescribing information of ceritinib. Data of alectinib was referred to the prescribing information of alectinib.
