Cheng 2003

Methods	Parallel design Aim: to treat depression and augment rehabilitation Randomisation: not stated Allocation concealment: not described Blinding: not described Analysis: according to allocated treatment group Drop‐outs: none
Participants	Location: China Setting: inpatient Treatment: 25 people Control: 32 people Whole group (including non‐depression group, depression control group and depression treatment group): 132 (mean age 62 ± 12 years, 79 men) Stroke: ischaemic stroke or PICH, clinical diagnosis plus confirmation on brain imaging (not clear that a stroke lesion had to be present), clear consciousness Depression diagnosis (at 2 weeks after stroke onset): psychiatric interview, DSM IV criteria
Interventions	Treatment: fluoxetine 20 mg daily Control: no fluoxetine Duration of treatment: 6 months Duration of follow‐up (post‐treatment to study end): 6 months
Outcomes	SSS ADL HAMD Zung SDS Zung SAS No deaths, none left trial early No data on AEs
Notes	Excluded: major psychological trauma history in previous 1 year, severe mental retardation, severe impairment of lingual expression or comprehension, major complicated medical event in previous 1 year
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not described
Allocation concealment (selection bias)	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	59 patients were diagnosed to have depression by symptoms but only 57 were included in the results table
Selective reporting (reporting bias)	High risk	No protocol, no report of the results of the self rating anxiety scale
Other bias	Unclear risk	No clear description of differences between the treatment and control group. No description of funding
Blinding of participants and personnel (performance bias) All outcomes	High risk	No placebo
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described