Lötzke 2016.

Methods	Randomised controlled trial
Participants	Women with diagnosed stage I‐III breast cancer undergoing cytotoxic (neo)adjuvant or endocrine adjuvant treatment Recruited from a University Hospital's Interdisciplinary Breast Center Mean age 51.2 years N = 119
Interventions	• Iyengar yoga (yoga postures, breathing techniques), 12 weeks, once weekly for 20 minutes • Physical exercise, 12 weeks, once weekly for 20 minutes
Outcomes	Health‐related quality of life (European Organisation of Research and Treatment of Cancer QLQ‐30) at week 12 and week 24 Fatigue (EORTC QLQ‐C30 Fatigue Symptom Scale; 15‐item Cancer Fatigue Scale (CFS‐D)) at week 12 and week 24
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Participants were randomized to one of the two intervention groups." No information on procedure of randomisation
Allocation concealment (selection bias)	Unclear risk	No information on allocation concealment
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information on blinding
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information on blinding
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	"Three patients dropped out at t1 and finally 54 patients at t2 (59%). Reasons could not be documented clearly." Sample size was not large enough to compensate for dropouts.
Selective reporting (reporting bias)	Low risk	No protocol available but no hint of selective reporting
Other bias	Unclear risk	"The number of lessons varied from 5 to 12, and the lapse of time, in between the patients performed, varied from 6 weeks to 25 weeks. This variation was not considered in the analysis." Intervention period and compliance unclear