Vadiraja 2009.

Methods	Randomised controlled trial
Participants	Women with diagnosed stage II‐III breast cancer undergoing radiotherapy during the study period Recruited from 2 comprehensive cancer care centres Mean age 47.2 years N = 88
Interventions	• Integrated yoga programme (yoga postures, breathing techniques, relaxation with imagery, meditation), 6 weeks, 60 minutes at least 3 times a week (18–24 sessions in total) • Brief supportive therapy, 6 weeks, 15 minutes every 10 days (3–4 sessions in total)
Outcomes	Health‐related quality of life (European Organisation for Research in the Treatment of Cancer ‐ Quality of Life) at week 6 Anxiety (Hospital Anxiety and Depression Scale) at week 6 Depression (Hospital Anxiety and Depression Scale) at week 6 Fatigue (European Organisation for Research in the Treatment of Cancer ‐ Quality of Life) at week 6 Insomnia (European Organisation for Research in the Treatment of Cancer ‐ Quality of Life) at week 6
Notes	Duplicate publications separately reported different outcomes of the same trial.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"[...] participants [...] were randomized, via computer‐generated random numbers, to receive yoga (n = 44) or supportive therapy (n = 44) before intervention (prior to radiotherapy)."
Allocation concealment (selection bias)	Low risk	"Randomization was performed using opaque envelopes with group assignments. Personnel who had no part in the trial performed randomization. The envelopes were opened sequentially in the order of assignment during recruitment, with the names and registration numbers of the participants written on the covers. The order of randomization was verified with the hospital date of admission records for radiotherapy at study intervals to make sure that field personnel had not altered the sequence of randomization to suit the allocation of consenting participants into 2 study arms."
Blinding of participants and personnel (performance bias) All outcomes	High risk	"[...] it was not possible to mask the yoga intervention from the study participants."
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information on blinding of outcome assessment
Incomplete outcome data (attrition bias) All outcomes	High risk	5% dropout in yoga group and 25% dropout in control group
Selective reporting (reporting bias)	High risk	No protocol available. Duplicate publications separately reported different outcomes of the same trial. Complete outcome measures were not disclosed.
Other bias	Low risk	No hint of other bias