Beattie 2000.
Methods | Randomised controlled trial. Duration 10 weeks. | |
Participants | Adults (n = 109, men and women) resuming oral food intake after surgery. BMI < 20 kg/m2, TSF or MAMC <15th percentile or > 5% weight loss. Mean (SD) age dietary advice group 62.4 years (10.9 years) and in dietary advice and supplement group 54.4 years (19.4 years). 101 completed study, 5 dropouts in routine nutritional management group and 3 in supplement group. | |
Interventions | Routine nutritional management (n = 54) or routine nutritional management and 400 ml of a 1.5 kcal/ml nutritional supplement (n = 55). | |
Outcomes | Survival*, weight*, BMI*, MAMC*, TSF*, handgrip strength*, complication rate, wound infection, chest infection, antibiotic use, QOL. | |
Notes | Routine nutritional management provided by more than one dietitian and not described in the paper. Information on quality obtained from authors. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Randomisation was performed using a computer generated list of random numbers. |
Allocation concealment (selection bias) | Low risk | The allocation was not concealed physically but the list of numbers was not consulted until the participant was recruited. |
Blinding (performance bias and detection bias) Clinical outcomes | High risk | The paper states that assessments were not blinded to treatment. |
Blinding (performance bias and detection bias) Functional outcomes | High risk | The paper states that assessments were not blinded to treatment. |
Blinding (performance bias and detection bias) Nutritional outcomes | High risk | The paper states that assessments were not blinded to treatment. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 5 dropouts (2 lost to follow‐up, 3 required artificial nutritional support) in routine nutritional management group and 3 (1 transferred to intensive care unit, 2 required artificial nutritional support) in supplement group. |
Selective reporting (reporting bias) | Low risk | All outcomes are reported and data for analysis were extracted from the paper. Additional information on study quality obtained from authors. |
Other bias | Unclear risk | Baseline variables provided, but groups not similar ‐ group receiving advice plus supplements was younger than the advice only group. Routine nutritional management provided by more than one dietitian and not described in the paper. |