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. 2011 Sep 7;2011(9):CD002008. doi: 10.1002/14651858.CD002008.pub4

Paton 2004.

Methods Randomised controlled trial. 
 Duration 24 weeks. Intervention for 12 weeks and follow‐up to 24 weeks.
Participants Adults (n = 36, dietary advice and supplement group 8 men and 11 women mean (SD) age 39.5 years (14.3); dietary advice group 8 men and 9 women, mean (SD) age 38.4 years (19.3)) with tuberculosis and BMI <20.
10 participants lost to follow up, 4 in dietary advice and supplement group and 6 in dietary advice group.
Interventions Dietary advice to achieve a calculated target intake and 2 ‐ 3x 200 ml supplement (n = 15) versus instruction to increase food intake (n = 13).
Outcomes Weight*, BMI, body composition (DEXA), energy intake*, grip strength*, QoL, stand/sit test.
Notes Additional data requested from author.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Sequence generated by a member of staff not otherwise involved in the study.
Allocation concealment (selection bias) Low risk Described as shuffling of sealed opaque envelopes.
Blinding (performance bias and detection bias) 
 Clinical outcomes Unclear risk Not stated.
Blinding (performance bias and detection bias) 
 Functional outcomes Unclear risk Not stated.
Blinding (performance bias and detection bias) 
 Nutritional outcomes Unclear risk Not stated.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk 10 participants lost to follow up, 4 in dietary advice and supplement group and 6 in dietary advice group.
Selective reporting (reporting bias) Low risk All specified outcomes reported but some in unusable format. Data on change in energy intake was presented in the text and not suitable for entry into meta‐analysis therefore obtained from author. Other data were extracted from the paper although 'n' for weight and grip strength were clarified with the authors.
Other bias Low risk Baseline variables given, groups similar at baseline.