Singh 2008.
Methods | Randomised controlled trial. Duration 3 months. | |
Participants | Adults (n = 60) with chronic pancreatitis, (male n = 50 and females n = 10), dietary advice group mean age 32 (SD 10) years, nutritional supplement group mean age 28 (SD 10) years. All patients undernourished, BMI <18.5 kg/m2 or >10% weight loss in previous 6 months. 6 dropouts. |
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Interventions | Dietary advice from a dietitian to meet predicted energy requirements (n = 25) versus a MCT‐enriched nutritional supplement to meet predicted energy requirements (n = 24). | |
Outcomes | BMI*, TSF*, MAMC* nitrogen balance, faecal fat, pain score. | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated random number list. |
Allocation concealment (selection bias) | Low risk | Carried out by individual not otherwise involved in the study. |
Blinding (performance bias and detection bias) Clinical outcomes | Low risk | Outcome assessment blinded to treatment. |
Blinding (performance bias and detection bias) Functional outcomes | Low risk | Outcome assessment blinded to treatment. |
Blinding (performance bias and detection bias) Nutritional outcomes | Low risk | Outcome assessment blinded to treatment. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Dietary counselling group: 2 lost to follow‐up at 1 and a half months. Nutritional supplement group: 4 lost to follow‐up at 1 and a half months. But all included in the final analysis. |
Selective reporting (reporting bias) | Low risk | All outcomes reported but not in a format usable for meta analysis. Data on change in weight, TSF, MAC and energy intake were reported as mean (SD) at baseline and mean (SD) at end of intervention, therefore mean change (SD) obtained from authors. |
Other bias | Low risk | Baseline variables given, groups similar at baseline |