NCT02319785

Trial name or title	Effects of robot‐assisted combined therapy in upper limb rehabilitation in stroke patients
Methods	Randomised cross‐over trial
Participants	Country: Taiwan Participants: estimated enrolment n = 120 Inclusion criteria: age 18 to 80 years; first‐ever unilateral stroke > 3 months after onset; upper extremity FMA score between 18 to 56 points; no excessive spasticity in the affected upper extremity; being able to follow study instructions and to perform study tasks; written informed consent Exclusion criteria: neural or psychological problems that may interfere with study; severe joint pain; upper limb fracture within the last 3 months; participation in any other research
Interventions	Experimental group 1: robot‐assisted therapy and neuromuscular electrical stimulation for 1.5 hours per day, 5 days a week for 4 weeks Experimental group 2: robot‐assisted therapy and mirror therapy for 1.5 hours per day, 5 days a week for 4 weeks Experimental group 3: mirror therapy for 1.5 hours per day, 5 days a week for 4 weeks Experimental group 4: unilateral robot‐assisted therapy (InMotion device) for 1.5 hours per day, 5 days a week for 4 weeks Experimental group 5: bilateral robot‐assisted therapy (Bi‐Manu‐Track) for 1.5 hours per day, 5 days a week for 4 weeks Control group (active): conventional rehabilitation for 1.5 hours per day, 5 days a week for 4 weeks
Outcomes	Outcomes will be collected at baseline and at the end of study at 4 weeks Primary outcomes: kinematic analyses FMA Secondary outcomes: 10‐meter walk test WMFT FIM ARAT Other outcome measures: MRC Functional Ambulation Categories MAS MAL ABILHAND questionnaire SIS 3.0
Starting date	August 2014
Contact information	Keh‐Chung Lin; kehchunglin@ntu.edu.tw Chung‐Shan Hung; f00429003@ntu.edu.tw
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