Carizza 2008

Methods	Parallel, single‐centre randomised controlled trial Computer‐based randomisation Cabergoline vs no intervention Setting: Brazil
Participants	166 women undergoing IVF and ICSI treatment and at risk of developing OHSS, defined as serum E2 > 4000 pg/mL on the day of hCG administration Exclusion criteria: not stated Cabergoline group: 83 women Control group: 83 women, 3 women were withdrawn for not completing the follow‐up tests No differences between groups in age or BMI Did not report the duration of infertility and causes of infertility
Interventions	All participants received routine preventive IV HA 20 g on the day of oocyte retrieval Cabergoline group: cabergoline 0.5 mg/day for 3 weeks from the day after oocyte retrieval Control group: no intervention
Outcomes	Moderate and severe OHSS identified by the modified classification of Golan and colleagues (Golan 1989) Severe OHSS (cabergoline group vs control group): 2/83 vs 1/83 Moderate OHSS (cabergoline group vs control group): 7/83 vs 14/83 Live birth rate: not stated Miscarriage rate (cabergoline group vs control group): 1/83 vs 3/83 Clinical pregnancy rate (cabergoline group vs control group): 33/83 vs 32/83 Multiple pregnancy rate (cabergoline group vs control group): multiple pregnancies were documented in all the severe cases of OHSS in both groups (2/83 vs 1/83) Any other adverse effects of the treatment: not stated
Notes	Authors reported no financial or commercial conflicts of interest
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐based randomisation
Allocation concealment (selection bias)	Unclear risk	Lack of sufficient information to permit judgement
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Lack of sufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	3/200 women in control group could not complete their follow‐up
Selective reporting (reporting bias)	Unclear risk	No exclusions (no live birth rated mentioned)
Other bias	Unclear risk	Lack of sufficient information to permit judgement