Jellad 2016

Methods	Single‐centre, prospective randomised study ("randomly divided in two groups") Cabergoline vs no medication Setting: Tunisia
Participants	146 women undergoing IVF or ICSI and receiving GnRHa. OHSS risk defined as a plasma E2 level > 3000 pg/mL on the day of hCG administration or the development of ≥ 18 follicles > 12 mm in diameter, or both Exclusion criteria: coasting cases, aged > 40 years, history of uterine surgery, and submucosal and intramural fibromas > 5 cm Cabergoline group: 78 women Control group: 68 women
Interventions	Cabergoline group: cabergoline 0.5 mg/day for 8 days starting on the day of hCG injection Control group (no intervention): no medication treatment
Outcomes	Moderate and severe OHSS identified according to the criteria of Golan and colleagues (Golan 1989) Severe OHSS (cabergoline group vs control group): 2/78 vs 8/68 Moderate OHSS (cabergoline group vs control group): 8/78 vs 17/68 mild, moderate or severe OHSS (cabergoline group vs control group): 25/78 vs 25/68 Live birth rate: not stated Miscarriage rate: only reported for women who developed OHSS (cabergoline group vs control group): 3/25 vs 6/25 Clinical pregnancy rate only reported for women who developed OHSS (cabergoline group vs control group): 20/25 vs 14/25 Multiple pregnancy rate: not stated Any other adverse effects of the treatment: not stated
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Lack of information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Lack of information to permit judgement
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Lack of information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	High risk	No follow‐up data from the non‐OHSS women in both groups, no data on possible loss to follow‐up or dropout
Selective reporting (reporting bias)	High risk	Pregnancy data from the non‐OHSS women in both groups not reported
Other bias	High risk	Coasting cases (women at highest risk for severe OHSS) were excluded, unclear based on what criteria coasting was opted for