Shaltout 2012

Methods	Randomised controlled trial Computer‐based randomisation Cabergoline vs no intervention Setting: Egypt
Participants	200 women undergoing ICSI treatment and at risk of developing OHSS, defined by E2 level on day of hCG > 3500 pg/mL with ≥ 20 follicles > 12 mm diameter Cabergoline group: 100 women; 2 had empty follicles, 2 had failure of fertilisation and 1 discontinued Control group: 100 women; 3 had empty follicles and 1 had failure of fertilisation Exclusion criterion: E2 ≥ 5000 pg/mL No differences between the groups in age, BMI and causes of infertility
Interventions	Cabergoline group: cabergoline tablet 0.25 mg/day for 8 days from the day of hCG injection Control group: no intervention
Outcomes	Moderate and severe OHSS identified according to Golan and colleagues (Golan 1989) Severe OHSS (cabergoline group vs control group): 1/100 vs 3/100 Moderate OHSS (cabergoline group vs control group): 4/100 vs 11/100 Live birth rate (cabergoline group vs control group): 37/100 vs 36/100 Miscarriage rate (cabergoline group vs control group): 5/100 vs 5/100 Clinical pregnancy rate (cabergoline group vs control group): 42/100 vs 41/100 Multiple pregnancy rate: not stated Any other adverse effects of the treatment: not stated
Notes	Number of women excluded for dropout (no ET because no oocytes found, no embryos yielded, etc., 1 adverse event)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐based randomisation method
Allocation concealment (selection bias)	Unclear risk	Lack of sufficient information to permit judgement
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Lack of sufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	9 women could not complete their follow‐up but exact reasons not stated
Selective reporting (reporting bias)	Low risk	Most outcomes were included
Other bias	Unclear risk	Lack of sufficient information to permit judgement