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. Author manuscript; available in PMC: 2020 Jan 7.
Published in final edited form as: Mol Pharm. 2018 Dec 14;16(1):238–246. doi: 10.1021/acs.molpharmaceut.8b00966

Fig. 5.

Fig. 5.

Concentration-dependent inhibitory effect of ethinylestradiol, fidaxomicin, troglitazone sulfate, norgestimate, atorvastatin, glycochenodeoxycholate and troglitazone on OSTα/β-mediated DHEAS transport. OSTab and Mock cells were preincubated with inhibitors for 10 min (Method 1; 0–200 μM) prior to the 30-s uptake with [3H]-dehydroepiandrosterone sulfate (DHEAS; 200 nCi/ml; 4 μM) at 37°C. Data are expressed as percentage of vehicle control; each value represents the mean ± SD of two independent experiments, each performed in triplicate. For troglitazone, only one experiment is shown (mean ± range).