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. 2018 Dec 30;105(5):1187–1195. doi: 10.1002/cpt.1296

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© 2018 Eli Lilly and Company. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Creatinine‐corrected urine kidney injury molecule (KIM)‐1 and neutrophil gelatinase‐associated lipocalin (NGAL) concentrations following a single oral dose of placebo or 400 mg abemaciclib with a single oral dose of 1,000 mg metformin or a single infusion of 3.235 g iohexol in healthy subjects up to 96 hours postdose. The middle line in each box plot represents the median, the top and bottom margins of the box represent the 75th and 25th percentiles. The whiskers extend to the 90th and 10th percentiles. Data extending beyond the 90th and 10th percentiles are plotted individually.