Table 1.

Paired-label biodistribution of [¹⁸F]TFPFN-2Rs15d and [¹²⁵I]SGMIB-2Rs15d in athymic mice bearing SKOV-3 xenografts.

	Percent injected dose per grama
Tissue	1 h		2 h		3 h
	125I	18F	125I	18F	125I	18F
Liver	0.36 ± 0.06	0.81 ± 0.18	0.64 ± 0.18	0.27 ± 0.07	0.39 ± 0.02	0.16 ± 0.01
Spleen	0.17 ± 0.03	0.69 ± 0.29	0.24 ± 0.05	0.17 ± 0.03	0.15 ± 0.02	0.10 ± 0.03c
Lungs	0.49 ± 0.12	0.89 ± 0.26	0.74 ± 0.76	1.15 ± 1.49c	0.27 ± 0.07	0.28 ± 0.04c
Heart	0.16 ± 0.03	0.29 ± 0.06	0.20 ± 0.08	0.15 ± 0.08	0.12 ± 0.02	0.11 ± 0.04c
Kidneys	39.04 ± 5.87	15.82 ± 3.88	30.16 ± 11.68	6.62 ± 5.83	9.01 ± 3.06	1.05 ± 0.45
Stomach	0.45 ± 0.19	0.17 ± 0.13	2.04 ± 0.79	0.72 ± 0.35	0.62 ± 0.57	0.08 ± 0.03c
Sm. Int.	0.26 ± 0.12	0.19 ± 0.04c	0.57 ± 0.20	0.16 ± 0.06	0.14 ± 0.04	0.05 ± 0.01
Lg. Int.	0.10 ± 0.03	0.13 ± 0.03c	0.38 ± 0.30	0.13 ± 0.07c	0.32 ± 0.34	0.08 ± 0.04c
Muscle	0.10 ± 0.04	0.16 ± 0.08c	0.17 ± 0.04	0.14 ± 0.03c	0.07 ± 0.02	0.05 ± 0.01c
Blood	0.23 ± 0.03	0.84 ± 0.10	0.28 ± 0.04	0.49 ± 0.16	0.36 ± 0.42	0.43 ± 0.30c
Bone	0.15 ± 0.07	0.32 ± 0.08b	0.19 ± 0.13	0.39 ± 0.13	0.11 ± 0.03	0.29 ± 0.17
Brain	0.02 ± 0.01	0.05 ± 0.02	0.03 ± 0.01	0.03 ± 0.01c	0.01 ± 0.00	0.02 ± 0.00
Tumor	3.87 ± 1.35	3.73 ± 1.14c	3.30 ± 1.26	2.94 ± 0.94c	3.56 ± 1.73	2.92 ± 1.44c

^a%ID/gram, Mean ± SD (n=5 at 1 h; n=4 at 2 h and 3 h)

^bn = 4

^cDifference in the uptake between the two tracers statistically NOT significant.