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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Trends Cell Biol. 2019 Mar 6;29(5):385–395. doi: 10.1016/j.tcb.2019.02.005

Figure 2: Models of Disp intracellular trafficking.

Figure 2:

A) Newly synthesized Disp is trafficked to the basolateral surface of cells to be cleaved at the cell surface by Furin [32–34,66]. B) Cleavage is thought to allow for internalization of mature Disp with the early endosomal marker Rab5 [34], for eventual apical trafficking. C) Apical Disp may then associate with membrane tethered Hhs for reinternalization in Rab5-positive endosomes [33,38]. Disp/Hhs containing vesicles may then be, D) recycled back to the apical surface in Rab4 positive vesicles [38] for Hh release, or E) sent to the MVB for basolateral surface presentation [33,39].