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| Study | Comparison | Instrument | Measure | Outcome | Intervention | Effect |
| KEEPS 2012 | Oestrogen (CEE or oestradiol) + cyclic oral micronised progesterone 200 mg/d × 12 days per month vs placebo (n = 275) for 48 months |
Modified Mini Mental State Examination (MMSE) | Differences between intervention and placebo groups in mean rate of change over time | Global cognition | 0.45 mg/d oral CEE (n = 230) | P = 0.178 |
| 0.05 mg/d transdermal oestradiol (n = 222) | P = 0.840 |
