Date	Event	Description
31 October 2012	Amended	Correction to 'Characteristics of included studies' table and description of studies, related to sample numbers for ESPRIT 2002 and HERS 1998 No change to data or analyses
3 February 2012	New citation required and conclusions have changed	Search updated to February 2012 New studies: Greenspan 2005;Nielsen 2006;Pefanco 2007;Tierney 2009 Updated WHI 1998 for the following outcomes: lung cancer (Chlebowski 2009, Chlebowski 2010a), breast cancer (Chlebowski 2010), cognition in older women (Espeland 2010; Resnick 2009), colorectal cancer (Prentice 2009a; Ritenbaugh 2008), clinical outcomes at 7.1 and 10.7 yrs in oestrogen‐only HT arm (LaCroix 2011) and at 7.9 years in combined arm (Heiss 2008) Updated EPHT for quality of life (Veerus 2008) Updated WISDOM for quality of life (Welton 2008) Reclassified equivalent HT doses in line with Australian Menopause Society recommendations: amended table of comparisons for studies using oral oestradiol (n = 10) Added 'Summary of findings' table and absolute risks, updated Discussion and Conclusions sections
11 February 2009	New citation required but conclusions have not changed	Review updated June 2008
31 May 2008	New search has been performed	Added the following new studies: Barakat 2006, EPHT 2006, WISDOM 2007, Yaffe 2006. WHI 1998oestrogen‐only arm, data added: Venous thromboembolism at 2 & 7.1 years' follow‐up Coronary heart disease, venous thromboembolism, stroke, breast cancer, fracture and quality of life at 7.1 years' follow‐up WHI 1998combined arm, data added: Subgroup analysis of breast cancer risk by prior hormone summarised in the text (Discussion section) Data on main outcomes after 3 years post intervention (Discussion section) Results from WHI 1998 (WHISCA) on specific cognitive functions in older women added to the text No substantial changes to overall findings of this review. Statistically significant risk of venous thromboembolism for WHI oestrogen‐only arm now evident at follow‐up "up to 2 years"
18 May 2008	Amended	Converted to new review format
20 November 2003	New citation required and conclusions have changed	Substantive amendments made