Table 1.

Fixed parameter values and adjustable parameters with their ranges used in the mechanistic model analysis of control, short-term HS, short-term HS with saline infusion and short-term HS with ANG II infusion.

Fixed Parameters
Parameter Name	Description	Value	Units
RAB	Cerebral arterial resistance to flow	500	(mmHg*s)/mL
RVB	Cerebral venous resistance to flow	1700	(mmHg*s)/mL
RAtlB,0	Cerebral arteriolar reference resistance to flow	2500	(mmHg*s)/mL
CAB	Cerebral arterial vasculature capacitance	0.0105	mL/mmHg
CVB	Cerebral venous vasculature capacitance	0.0500	mL/mmHg
AENcol	Arteriolar non-collagen content-stiffness product	2.01e3	mmHg
AECol	Arteriolar collagen content-stiffness product	8.77e6	mmHg
α	Arteriolar collagen distribution characteristic strain	1.24	unitless
γ	Arteriolar collagen distribution shape factor	7.11	unitless
DAtl,0	Arteriolar reference diameter	189.8	μm
AWall	Arteriolar circumferential wall area	8405	μm2
TDAtl	Arteriolar diameter time constant	1	s
TAAtl	Arteriolar activation time constant	15	s
Adjustable Parameters
Parameter Name	Description	Range	Units
CAct0	Arteriolar strength of smooth muscle	1–10	mmHg*μm
CActl	Arteriolar position of peak tension generation	0.5–1.3	unitless
CAct2	Arteriolar width of smooth muscle diameter-tension curve	0.1–1.0	unitless
CTone0	Arteriolar smooth muscle activation sensitivity to stress	0–25	1/(mmHg*μm)
CTonel	Arteriolar smooth muscle activation baseline tone factor	0–25	unitless