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(A) In cells expressing SLC30A10-WT Mn is immediately excreted by the SLC30A10 protein expressed at the plasma membrane. (B) In cells expressing the mutant, the SLC30A10-Δ105-107 protein is blocked in the ER and cannot be translocated to the plasma membrane resulting in Mn uptake in the cytoplasm. Mn is pumped from the cytoplasm into the Golgi vesicles by SPCA1 resulting in Mn accumulation in Golgi vesicles.
