Tari 2009.

Study characteristics
Methods	Study design: quasi‐randomised controlled trial Multicentre or single‐centre: single‐centre Setting: Tehran University Eye Research Center, Tehran, Iran Period: January 2006 to June 2007 Sample size: not reported Follow up: 11.56 months for non‐integrated group and 13.16 months for integrated group
Participants	100 patients. Mean age: 42.32 years for evisceration group and 39.56 years for enucleation group Sex: 15 women and 35 men for evisceration group; and 9 women and 41 men for evaluation group Inclusion criteria: not reported Exclusion criteria: significant preoperative motility abnormalities, cases of severe phthisis, and cases that were not followed up for at least 4 months
Interventions	Enucleation with HA (integrated group) (n = 50) versus evisceration plus quadrisection of sclera with alloplastic implantation (non‐integrated group) (n = 50) There was no peg device. Enucleation via the traditional technique and evisceration plus scleral quadrisection
Outcomes	The primary outcome was the presence or absence of exposure or extrusion and deep superior sulcus deformity, and the secondary outcome was implant motility measured by detecting the amount of overlying conjunctival movement.
Notes	Reasons for surgery were: painful blinded eye, cosmetic unacceptability, acute trauma, and endophthalmitis. The reason for the surgery was the same for both groups. However, all the trauma patients had enucleation and all the endophthalmitis patients had evisceration. There was no financial support.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Participants were randomly divided in 2 groups for alternate surgical plans including enucleation with HA implantation or evisceration plus quadrisection of sclera with alloplastic implantation.
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed the study.
Selective reporting (reporting bias)	Low risk	No evidence
Other bias	Low risk	No evidence. The authors declare no financial support or relationships that may pose a conflict of interest.

HA: hydroxyapatite; PMMA: polymethylmethacrylate; PP: porous polyethylene.