Domain	Judgement (circle)	Description (for quotation, use exclamation marks)
Are reports of the study free of suggestion of selective outcome reporting? Have the outcome data been analysed according to the method/protocol stated? If not, please specify the differences, including outcome measures not reported in the analysis	Yes/No/Unclear
Was the study apparently free of other problems that could put it at high risk of bias? Were groups comparable on trial entry? If not, specify the differences. Is there likelihood of serious carryover effects between treatments in cross‐over trials, i.e. was the washout period between treatments adequate? Did all participants in all groups have outcomes measured in the same way? If not, please specify the differences. Were measurement tools validated appropriately? If not, specify why the outcome measure may be prone to bias. Did intervention and comparison groups receive identical management and standard care during the trial, except for the intervention of interest? If not, specify differences in management or standard care	Yes/No/Unclear