Comparison 2. Constraint versus control: subgroup analysis on primary outcome.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Amount of task practice	11		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 ≤ 30 hours	8	253	Std. Mean Difference (IV, Fixed, 95% CI)	0.18 [‐0.07, 0.44]
1.2 > 30 hours	3	91	Std. Mean Difference (IV, Fixed, 95% CI)	0.25 [‐0.18, 0.67]
2 Anatomical region restraint	11		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Arm plus hand	2	61	Std. Mean Difference (IV, Fixed, 95% CI)	0.35 [‐0.17, 0.87]
2.2 Hand only	9	283	Std. Mean Difference (IV, Fixed, 95% CI)	0.17 [‐0.08, 0.41]
3 Time since stroke	7		Std. Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 0 to 3 months	5	164	Std. Mean Difference (IV, Fixed, 95% CI)	0.07 [‐0.26, 0.39]
3.2 3 to 9 months	0	0	Std. Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 More than 9 months	2	62	Std. Mean Difference (IV, Fixed, 95% CI)	0.49 [‐0.02, 1.00]