Alberts 2004.

Methods	Randomisation automated and balanced with respect to sex, premorbid handedness, side of stroke and level of function Blinded outcome assessor No information about withdrawals Multicentre, outpatients
Participants	USA Recruited from 247 facilities spanning the 7 participating sites participating in a multi‐site trial 10 participants: 5 intervention, 5 control Inclusion criteria: cerebrovascular accident between 3 and 9 months, 10° of active extension to the metacarpophalangeal and interphalangeal joints and 20° at wrist, minimum passive range of motion of 90° for shoulder flexion and abduction Exclusion criteria: score of < 24 on the MMSE, physician‐determined major medical problems that would interfere with participation Mean age (SD): intervention group: 65 (8.2) years, control group: 63.4 (15.5) years % women: intervention group 60%, control group: 40% Stroke details: only ischaemic, 20% with right hemiparesis in each group Time since stroke, mean (SD): intervention group 6.4 (1.1) months, control group 5.6 (1.5) months
Interventions	CIMT versus no treatment CIMT: shaping or adaptive task practice and repetitive task practice techniques Amount of restraint: 90% of waking hours per day Anatomical region restraint: hand Session duration: 6 hours per day, 5 days per week for 2 weeks
Outcomes	Measures pre/post treatment Arm motor function: WMFT Arm motor impairment: FMA, grip/force
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Sequence generation by random automated generator Quote: "Ten patients were randomly assigned to 1 of 2 groups"
Allocation concealment (selection bias)	Low risk	Central allocation
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "An evaluator blinded to group assignment performed pre‐ and post‐ WMFT and FMA assessments"
Incomplete outcome data addressed? (Post‐treatment)	Unclear risk	The study provided no information about withdrawals