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. 2015 Oct 8;2015(10):CD004433. doi: 10.1002/14651858.CD004433.pub3

Wu 2007a.

Methods Randomisation details were not reported
 Blinded outcome assessor
 No withdrawals
 Multicentre, inpatients/outpatients
Participants Taiwan
Recruited from the rehabilitation departments of 2 medical centres (Chang Gung Memorial Hospital and National Taiwan University Hospital)
30 participants: 15 intervention, 15 control
Inclusion criteria: cerebrovascular accident between 12 and 36 months; 10° of active extension to the finger and 20° at wrist; non‐use of the more affected upper extremity (AoU score < 2.5 on the MAL); no serious cognitive deficits
Exclusion criteria: balance problems sufficient to compromise safety when wearing the study’s constraint device; excessive spasticity in any joint of the affected upper extremity
Mean age (SD): intervention group: 54.66 (8.63) years, control group: 53.31 (6.29) years
 % women: intervention group 47%, control group: 40%
Stroke details: 40% with right hemiparesis in treatment group, 33% with right hemiparesis in control group
Time since stroke, mean (SD): intervention group 18.53 (6.92) months, control group 17.61 (7.55) months
Interventions mCIMT versus control
mCIMT: functional tasks by shaping techniques with the affected arm, normalisation of muscle tone
 Amount of restraint: 6 hours per day
Anatomical region restraint: hand
Control: neurodevelopmental therapy emphasising balance training, stretching/weight bearing of the affected arm, fine‐motor dexterity training in addition to practice on ADL with the less affected side
Session duration: 2 hours per day, 5 days per week, 3 weeks for each group
Outcomes Measures pre/post treatment
  • Perceived arm motor function: MAL

  • ADL measure: FIM

  • Kineatic variables

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "... subjects were randomized with equal probability"
 Comment: insufficient information to permit judgment
Allocation concealment (selection bias) Unclear risk No information provided
Blinding (performance bias and detection bias) 
 All outcomes Low risk Quote: "A certified occupational therapist blind to study hypothesis and subject allocation was trained to administer the assessments"
Incomplete outcome data addressed? (Post‐treatment) Low risk No missing data