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. 2015 Oct 8;2015(10):CD004433. doi: 10.1002/14651858.CD004433.pub3

Wu 2007c.

Methods Randomisation by random‐numbers table, other details were not provided
 Blinded outcome assessor
 No withdrawals
 Multicentre, inpatients/outpatients
Participants Taiwan
Recruited from the rehabilitation departments of 3 medical centres
26 participants: 13 intervention, 13 control
Inclusion criteria: cerebrovascular accident between 0.5 and 31 months; Brunnstrom stage > 3 on arm section; non use of the more affected upper extremity (amount‐of‐use score < 2.5 on the MAL); no serious cognitive deficits
Exclusion criteria: balance problems sufficient to compromise safety when wearing the study's constraint device
Mean age (SD): intervention group: 71.44 (6.42) years, control group: 71.94 (16.79) years
 % women: intervention group 38%, control group: 46%
Stroke details: ischaemic or haemorrhagic; 46% with right hemiparesis in treatment group, 54% with right hemiparesis in control group, all participants had right hand dominance
Time since stroke, mean (SD): intervention group 6.70 (8.99) months, control group 8.32 (7.97) months
Interventions mCIMT versus usual care
 mCIMT: functional tasks by shaping techniques with the affected arm, normalisation of muscle tone
 Amount of restraint: 6 hours per day
Anatomical region restraint: hand
 Usual care: neurodevelopmental therapy emphasising functional task practice, stretching/weight‐bearing, fine‐motor dexterity training
 Session duration: 2 hours per day, 5 days per week, 3 weeks for each group
Outcomes Measures pre/post treatment
  • Perceived arm motor function: MAL

  • Arm motor impairment: FMA

  • ADL measure: FIM

  • Quality of life: SIS

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Subjects were individually randomized into the mCIMT or the traditional rehabilitation group by using a table of random numbers"
Allocation concealment (selection bias) Unclear risk No information provided
Blinding (performance bias and detection bias) 
 All outcomes Low risk Quote: "Before and after the 3‐week intervention period, the tests were administered in random order by a blinded rater"
Incomplete outcome data addressed? (Post‐treatment) Low risk No missing data