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. 2019 Apr 12;39(4):BSR20181960. doi: 10.1042/BSR20181960

Table 1. Relevant studies investigating the relationship between MMP-1-1607 (rs1799750) 1G/2G polymorphisms and OA.

Author Year Country Ethnicity Type of disease Study design Sample size of case/control Genotyping methods HWE among controls Results
Luo et al. 2015 China Asian TMJ OA Case–control 206/185 PCR-RFLP 0.58 *
Lepetsos 2014 Greece Caucasian Knee OA Case–control 155/139 PCR-RFLP 0.06 NO
Yang et al. 2015 China Asian Knee OA Case–control 207/207 PCR-RFLP 0.97 NO
Abd-Allah et al. 2012 Egypt Caucasian Mixed Case–control 100/100 PCR-RFLP 0.63 *
Barlas et al. 2008 Turkey Caucasian Knee OA Case–control 157/84 PCR-RFLP 0.34 *
Rui et al. 2018 China Asian Knee OA Case–control 308/404 PCR-RFLP 0.4 *
*

A significant relevance between the MMP-1 polymorphism and risk of OA was picked up in this article. Abbreviations: PCR-RFLP, PCR-restriction fragment length polymorphism; TMJ OA, temporomandibular joint OA.