Table 1. Relevant studies investigating the relationship between MMP-1-1607 (rs1799750) 1G/2G polymorphisms and OA.
| Author | Year | Country | Ethnicity | Type of disease | Study design | Sample size of case/control | Genotyping methods | HWE among controls | Results |
|---|---|---|---|---|---|---|---|---|---|
| Luo et al. | 2015 | China | Asian | TMJ OA | Case–control | 206/185 | PCR-RFLP | 0.58 | * |
| Lepetsos | 2014 | Greece | Caucasian | Knee OA | Case–control | 155/139 | PCR-RFLP | 0.06 | NO |
| Yang et al. | 2015 | China | Asian | Knee OA | Case–control | 207/207 | PCR-RFLP | 0.97 | NO |
| Abd-Allah et al. | 2012 | Egypt | Caucasian | Mixed | Case–control | 100/100 | PCR-RFLP | 0.63 | * |
| Barlas et al. | 2008 | Turkey | Caucasian | Knee OA | Case–control | 157/84 | PCR-RFLP | 0.34 | * |
| Rui et al. | 2018 | China | Asian | Knee OA | Case–control | 308/404 | PCR-RFLP | 0.4 | * |
A significant relevance between the MMP-1 polymorphism and risk of OA was picked up in this article. Abbreviations: PCR-RFLP, PCR-restriction fragment length polymorphism; TMJ OA, temporomandibular joint OA.