. 2019 Apr 12;39(4):BSR20181960. doi: 10.1042/BSR20181960

Table 2. Meta-analysis for MMP-1-1607 polymorphism and OA risk.

Variables	n	2G vs. 1G		2G/2G + 2G/1G vs. 1G/1G		2G/2G vs. 1G/2G + 1G/1G		1G/2G vs. 2G/2G		2G/2G vs. 1G/1G
		OR (95% CI)	P_h	OR (95% CI)	P_h	OR (95% CI)	P_h	OR (95% CI)	P_h	OR (95% CI)	P_h
Total	6	1.12	0	1.25	0.001	1.23	0.57	0.73	0	1.31	0
		(0.78–1.60)		(0.79–1.97)		(0.63–2.41)		(0.32–1.67)		(0.57–2.98)
Type of disease
Knee OA	4	0.93	0	0.92	0.002	0.83	0	0.48	0	0.76	0
		(0.58–1.48)		(0.48–1.74)		(0.37–1.87)		(0.16–1.43)		(0.25–2.27)
Other	2	1.63	0.008	2.03	0.192	2.74	0	1.57	0.191	3.46	0.311
		(0.83–3.19)		(1.26–3.26)		(1.80–4.16)		(0.94–2.60)		(2.13–5.62)
Ethnicity
Asian	3	1.16	0.014	1.31	0.054	1.58	0.002	0.45	0	1.7	0
		(0.84–1.59)		(0.84–2.04)		(0.87–2.89)		(0.13–1.94)		(0.78–3.71)
Caucasian	3	1.07	0	1.09	0	0.94	0	1.14	0.024	0.95	0
		(0.44–2.59)		(0.35–3.34)		(0.21–4.34)		(0.45–2.61)		(0.13–6.92)

Random-effects model was used when the P-value for the heterogeneity test was <0.05; otherwise, a fixed-effects model was used. Abbreviations: n, number of studies; P_h, value of Q-test for heterogeneity test, value of Q-test for heterogeneity test.