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. 2019 Apr 16;39(4):BSR20190016. doi: 10.1042/BSR20190016

Figure 2. CHTOP knockdown inhibited the migration and invasion ability of epithelial ovarian cancer cells.

Figure 2

(A) OV-90 and SK-OV-3 cell lines showed enhanced migration capability as compared with IGROV-1 cell line. The migration potential was examined by wound-healing assay, and wound area was compared after 48 h. Representative images were obtained at 40× magnification. (B) OV-90 and SK-OV-3 cell lines showed enhanced invasion potential as compared with IGROV-1 cell line. The invasion potential was tested by Matrigel invasion assay. The number of cells invading through the Matrigel was counted and compared after 72 h from five randomly selective fields. Representative images were obtained at 100× magnification. (C,D) CHTOP knockdown significantly reduced the migration capability of OV-90 and SK-OV-3 cell lines. The migration activity was examined by wound-healing assay, and wound area was compared after 48 h. Representative images were obtained at 40× magnification. (E,F) CHTOP knockdown significantly reduced the invasion potential of OV-90 and SK-OV-3 cell lines. The number of cells invading through the Matrigel was counted and compared after 72 h from five randomly selective fields. Representative images were obtained at 100× magnification. Data were expressed as mean ± S.E.M. (n=3). *P<0.05 vs IGROV-1 or si-con group.