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. 2019 Apr 12;39(4):BSR20182266. doi: 10.1042/BSR20182266

Figure 5. cIAP1 inhibits apoptosis by NF-κB activation in GBC.

Figure 5

(A,B) The immunoprecipitation analysis prior co-treatment of TNF-α and cycloheximide showed Caspase-8 with RIP1 but knockdown of cIAP1 failed to enhance such interaction with reference to Input ones. (C,D) There was less translocation of NF-κB subunit P65 from plasma to nuclear in LV-shcIAP1 group under the stimulation of TNF-α for 6 h in both cell lines. (E–G) The expressions of c-FLIP in both transcriptional and translational levels were reduced in LV-shcIAP1 group in the stimulation of TNF-α (*P< 0.05, **P< 0.01). Similar results were assured at least triplicated.