Table 2. Stratified analysis of GAS5 rs55829688 genotypes associated with CRC risk.
| Variables | Genotypes (cases/controls) | P | Adjusted HR | |
|---|---|---|---|---|
| CC | CT/TT | (95% CI)1 | ||
| Age (years) | ||||
| ≤56 | 44/69 | 516/507 | 0.0203 | 1.57 (1.05–2.35) |
| >56 | 37/61 | 460/502 | 0.0572 | 1.52 (0.99–240) |
| Gender | ||||
| Male | 57/79 | 591/579 | 0.0576 | 1.39 (0.97–2.00) |
| Female | 24/51 | 385/430 | 0.0113 | 1.93 (1.16–3.21) |
| Location | ||||
| Colon | 35/130 | 432/1009 | 0.0188 | 1.61 (1.08–2.40) |
| Rectum | 46/130 | 544/1009 | 0.0184 | 1.55 (1.09–2.21) |
| Grade | ||||
| Low | 18/130 | 330/1009 | 0.0007 | 2.32 (1.39–3.87) |
| Intermediate/High | 63/130 | 646/1009 | 0.0840 | 1.34 (0.97–1.84) |
| Depth of invasion | ||||
| T1 | 3/130 | 32/1009 | 0.8876 | 1.99 (1.28–3.08) |
| T2 | 28/130 | 212/1009 | 0.9812 | 1.58 (1.10–2.28) |
| T3 | 20/130 | 178/1009 | 0.6013 | 1.43 (0.99–2.05) |
| T4 | 30/130 | 554/1009 | <0.0001 | 1.11 (0.72–1.69) |
| Lymph node metastasis | ||||
| N0 | 46/130 | 562/1009 | 0.0109 | 1.58 (1.11–2.25) |
| N1 | 35/130 | 414/1009 | 0.0333 | 1.54 (1.04–2.27) |
| Distant metastasis | ||||
| M0 | 70/130 | 870/1009 | 0.0023 | 1.62 (1.20–2.20) |
| M1 | 11/130 | 106/1009 | 0.5118 | 1.24 (0.65–2.37) |
| TNM | ||||
| I | 20/130 | 174/1009 | 0.6528 | 1.11 (0.67–1.82) |
| II | 24/130 | 366/1009 | 0.0097 | 2.01 (1.28–3.16) |
| III | 26/130 | 330/1009 | 0.0268 | 1.65 (1.06–2.57) |
| IV | 11/130 | 106/1009 | 0.5115 | 1.24 (0.65–2.37) |
1
Adjusted for age, gender in the logistic regression model.