Table 3. Combination analysis of miR-146 G/C, miR-196a2 C/T, and miR-499 C/T polymorphisms in Indian cervical cancer cases and controls.
| Genotype | Controls | Cases | P-value | OR (95% CI) |
|---|---|---|---|---|
| miR-146a/miR-196a2 | ||||
| CC/CC | 7 (4.67) | 13 (8.67) | 1.000 (Reference) | |
| CC/CT | 9 (6) | 8 (5.33) | 0.3309 | 0.4786 (0.1274–1.798) |
| CC/TT | 12 (8) | 0 (0)1 | 0.0004 | 0.02222 (0.001146–0.4310) |
| CG/CC | 17 (11.33) | 27 (18) | 1 | 0.8552 (0.2843–2.573) |
| CG/CT | 13 (8.67) | 13 (8.67) | 0.3767 | 0.5385 (0.1625–1.785) |
| CG/TT | 20 (13.33) | 9 (6) | 0.0234 | 0.2423 (0.07226–0.8125) |
| GG/CC | 18 (12) | 35 (23.33) | 1 | 1.047 (0.3553–3.085) |
| GG/CT | 29 (19.33) | 37 (24.67) | 0.607 | 0.6870 (0.2429–1.943) |
| GG/TT | 25 (16.67) | 8 (5.33) | 0.0045 | 0.1723 (0.05107–0.5814) |
| miR-146a/miR-499 | ||||
| CC/CC | 19 (12.7) | 14 (9.33) | 1.000 (Reference) | |
| CC/CT | 5 (3.33) | 6 (4) | 0.5093 | 1.629 (0.4125–6.430) |
| CC/TT | 4 (2.67) | 1 (0.67) | 0.6295 | 0.3393 (0.03408–3.377) |
| CG/CC | 30 (20) | 29 (19.33) | 0.6636 | 1.312 (0.5558–3.096) |
| CG/CT | 13 (8.67) | 12 (8) | 0.7913 | 1.253 (0.4404–3.563) |
| CG/TT | 5 (3.33) | 9 (6) | 0.2124 | 2.443 (0.6703–8.903) |
| GG/CC | 33 (22) | 34 (22.67) | 0.5245 | 1.398 (0.6034-3.240) |
| GG/CT | 30 (20) | 30 (20) | 0.5214 | 1.357 (0.5765–3.195) |
| GG/TT | 11 (7.33) | 15 (10) | 0.2993 | 1.851 (0.6539–5.238) |
| miR-196a2/miR-499 | ||||
| CC/CC | 26 (17.33) | 43 (28.67) | 1.000 (Reference) | |
| CC/CT | 11 (7.33) | 23 (15.33) | 0.6659 | 1.264 (0.5306–3.012) |
| CC/TT | 5 (3.33) | 9 (6) | 1 | 1.088 (0.3288–3.603) |
| CT/CC | 26 (17.33) | 28 (18.67) | 0.2732 | 0.6512 (0.3161–1.341) |
| CT/CT | 16 (10.67) | 19 (12.67) | 0.5266 | 0.7180 (0.3148–1.638) |
| CT/TT | 9 (6) | 11 (7.33) | 0.6085 | 0.7390 (0.2700–2.023) |
| TT/CC | 29 (19.33) | 7 (4.67) | <0.0001 | 0.1460 (0.05597–0.3806) |
| TT/CT | 22 (14.67) | 5 (3.33) | 0.0002 | 0.1374 (0.04636–0.4073) |
| TT/TT | 6 (4) | 5 (3.33) | 0.3328 | 0.5039 (0.1397–1.818) |
1
To make calculation possible, 0.5 was added to each value. Abbreviation: P-value, probability from chi-square test comparing the genotypic/allelic distribution in cervical cancer cases and controls. Significant P-values are shown in bold.