Table 1.
Isotype and CDR3 sequence analysis for the selected three heavy chains and five light chains from an H7N9-infected patient
| Heavy/light chain | V-gene and allele | D-gene and allele | J-gene and allele | CDR3 sequence | SHM nt (aa) | Frequency (%) |
|---|---|---|---|---|---|---|
| H1 | IGHV3–30–3*01 | IGHD3–16*01 | IGHJ4*03 | ARDPLTKLLPFDWVSGGYFDY | 19 (13) | 2.8 |
| H2 | IGHV2–5*02 | IGHD6–19*01 | IGHJ4*01 | AHFGQWLVYFDY | 7 (5) | 2.6 |
| H3 | IGHV3–30*01 | IGHD3–10*02 | IGHJ6*03 | ARDVYDFWSEPFNYDFCYMDV | 10 (7) | 1.9 |
| K1 | IGKV3–20*01 | - | IGKJ1*01 | QQYGSSFT | 5 (3) | 12.2 |
| K2 | IGKV2–30*01 | - | IGKJ1*01 or IGKJ4*01 | MQGTHWPLS | 9 (5) | 2.5 |
| K3 | IGKV1–39*01 or IGKV1D-39*01 | - | IGKJ1*01 | QQSYSTPYT | 7 (3) | 2.3 |
| L1 | IGLV3–1*01 | - | IGLJ1*01 | QAWDSSTVV | 0 (0) | 23.0 |
| L2 | IGLV2–14*01 | - | IGLJ1*01 | SSYTSSSTLV | 2 (1) | 4.4 |
aa amino acid, nt nucleotide, SHM somatic hypermutation