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. 2019 Apr 15;9:6078. doi: 10.1038/s41598-019-42523-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Agarose gel analysis of RT-PCR products showed exon-23 and exon-22/23 dual skipping in mdx mouse myotubes in vitro. Concentrations of AOs used include 12.5 nM, 25 nM, and 50 nM. (A) Fully modified 2′-OMe-PS control AO and fully modified 2′-F-PS AO; the original gel image is shown in Fig. S1 (A2) (Supplementary Information). (B) 2′-OMe modified 2′-F-PS AO chimeras including 2′-OMe/2′-F-PS gapmer, 2′-OMe/2′-F-PS mixmer 1, and 2′-OMe/2′-F-PS mixmer 2; the original gel image is shown in Fig. S1(B2) (Supplementary Information). (C) LNA modified 2′-F-PS AO chimeras including LNA/2′-F-PS gapmer, LNA/2′-F-PS mixmer 1, and LNA/2′-F-PS mixmer 2; the original gel image is shown in Fig. S1(C2) (Supplementary Information). The corresponding densitometry data of the gel images are shown in Fig. S1(A1, B1 and C1) (Supplementary Information).