Table 1.
List of AO names and sequences used in this study.
AO name | Sequence, 5′ → 3′ direction |
---|---|
Fully 2′-OMe-PS | GCCAAACCUCGGCUUACC |
Fully 2′-F-PS | GFCFCFAFAFAFCFCFUFCFGFGFCFUFUFAFCFCF |
2′-OMe/2′-F-PS gapmer | GCCFAFAFAFCFCFUFCFGFGFCFUFUFAFCC |
2′-OMe/2′-F-PS mixmer 1 | GCFCFAFAFAFCCFUFCFGFGCFUFUFAFCFC |
2′-OMe/2′-F-PS mixmer 2 | GFCFCFAFAFAFCFCFUCFGFGCFUFUAFCFC |
LNA/2′-F-PS gapmer | GLCLCFAFAFAFCFCFUFCFGFGFCFUFUFAFCLCL |
LNA/2′-F-PS mixmer 1 | GLCFCFAFAFAFCLCFUFCFGFGLCFUFUFAFCFCL |
LNA/2′-F-PS mixmer 2 | GFCFCFAFAFAFCFCFTLCFGFGLCFUFTLAFCFCL |
2′-OMe nucleotides are represented in underlined and bold letters; 2′-F nucleotides are represented in black letters with superscript F; LNA nucleotides are represented in underlined and bold-italic letters with superscript L. All AOs possess PS backbone.