Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 15;4:8. doi: 10.1038/s41525-019-0081-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Ontology analysis of 624 known prenatal-lethal genes, compared with all 3187 OMIM genes. a Comparative analysis of gene ontology between dominant (AD or X-linked dominant) and recessive (AR or X-linked recessive) prenatal-lethal genes. Gene ontology terms for each gene were compiled, then GO terms comparatively enriched in either dominant or recessive gene families were determined (subcellular localisation, molecular function and biological processes). Comparative metrics were exported from cytoscape with a p-value cutoff of 0.025 with data visualisation performed in R. Green: GO terms significantly comparatively enriched among Dominant lethal genes, with intensity of colour correlating with the proportion of genes in category annotated with that term. Purple: GO terms significantly comparatively enriched terms among Recessive lethal genes. b Comparative analysis of gene ontology between dominant and recessive among all 3187 OMIM genes. Ontology analyses is available in https://github.com/RubyDawes/GD_Informatics_Toolkit/releases/tag/v1.0.0. Highly general terms are excluded from the figure (cellular component, cell, binding etc.). Some ontology terms are abbreviated for readability. Only the 14 most significantly overrepresented categories are visualised