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. 2019 Apr 15;9:6071. doi: 10.1038/s41598-019-42537-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hc-cath limits an LPS induced inflammatory response from macrophages. THP-1 macrophages were stimulated with increasing concentrations of Hc-cath (a) (0.28 µM, 2.80 µM or 13.78 µM) or staurosporine or left untreated (un). Viability was determined after 16 hr. (b,c) ELISA analysis of IL-8 and IL-6 release from differentiated THP1 macrophages 16 hr after stimulation with Pseudomonas LPS (100 ng/ml) in combination with 0.28 µM or 1.34 µM Hc-cath. Data are presented as mean ± SEM. Means between groups (untreated vs LPS and LPS versus LPS + Hc-cath) were compared by Mann Whitney t-test. ^*Indicates P < 0.05.