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. 2019 Apr 15;10:1735. doi: 10.1038/s41467-019-09587-y

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — In vitro catheter injection of low-viscosity progelators. a Complex viscosity of KLDL_Cyclic (blue triangles) and KFDF_Cyclic (blue circles) progelators reveal >20× decrease in comparison to corresponding unmodified KLDL (black triangles) and KFDF (black circles) self-assembling peptides (SAPs). b Schematic illustrating catheter applicability of KLDL and KFDF SAPs vs that of enzyme-responsive KLDL_Cyclic and KFDF_Cylic progelators. Injection of SAP hydrogels causes clogging. Clipart adapted from Servier’s Medical Art database (https://smart.servier.com). c Experimental setup of progelator (2 mol% labeled) catheter injection test. Peptide was (1) loaded in a 1 mL syringe, (2) mounted on a syringe pump, and (3) flowed at 0.6 mL min⁻¹ through the inner nitinol tubing (27 G) of a MyoStar transendocardial injection catheter. The catheter was (4) submerged in a circulating water bath heated to 37 °C. The collection tube (5) before (top) and after (bottom) injection shows successful injection. d Photographs of KLDL_Cyclic and KFDF_Cyclic progelators (2 mol% labeled) after catheter injection into an empty vial (left) or a vial containing thermolysin (right), demonstrating that injection does not disrupt enzyme responsiveness. Progelator formulated as 10 mM in 1× Dulbecco's phosphate-buffered saline (DPBS; pH 7.4) and treated with 1:4500 enzyme/substrate molar ratio