Table 1.
Characteristics at baseline.
| Total (n = 60) | Responders (n = 38) | Non-responders (n = 22) | p value | |
|---|---|---|---|---|
| Age(year) | 69 ± 10 | 68 ± 10 | 69 ± 10 | 0.820 |
| Female sex | 15%(9) | 18%(7) | 9%,(2) | 0.464 |
| BMI(kg/m²) | 28 ± 5 | 27 ± 5 | 29 ± 5 | 0.281 |
| Hypertension | 55%(33) | 58%(22) | 50%(11) | 0.561 |
| Dyslipidemia | 62%(37) | 55%(21) | 73%(16) | 0.186 |
| Obesity | 32%(19) | 29%(11) | 36%(8) | 0.560 |
| Diabetes mellitus | 28%(17) | 21%(8) | 41%(9) | 0.103 |
| History of Heart Failure | 55%(33) | 50%(19) | 64%(14) | 0.314 |
| Chronic Respiratory Insufficiency | 15%(9) | 5%(2) | 32%(7) | 0.006 |
| Denutrition | 3%(2) | NA | 9%(2) | 0.060 |
| Non-ischemic cardiomyopathy | 42%(25) | 55%(21) | 18%(4) | 0.005 |
| IHM | 45%(27) | 29%(11) | 73%(16) | 0.001 |
| Heart Rate(bpm) | 68 ± 11 | 66 ± 10 | 71 ± 13 | 0.140 |
| NYHA | 2.41 ± 0.65 | 2.16 ± 0.68 | 2.25 ± 0.59 | 0.153 |
| 6MWT(m) | 365 ± 167 | 385 ± 187 | 326 ± 116 | 0.216 |
| MLWHFQ | 32 ± 18 | 29 ± 18 | 39 ± 15 | 0.031 |
| QRS duration(ms) | 163 ± 24 | 172 ± 22 | 147 ± 19 | < 0.001 |
| LBBB | 52%(31) | 63%(24) | 32%(7) | 0.019 |
| NICD | 27%(16) | 13%(5) | 50%(11) | 0.002 |
| RBBB | 5%(3) | 3%(1) | 9%(2) | 0.276 |
| Paced | 17%(10) | 21%(8) | 9%(2) | 0.238 |
| Estimated GFR(/ml/min/1.73 m²) | 69.1 ± 24.6 | 71.8 ± 24.5 | 64.5 ± 24.8 | 0.272 |
| NT-ProBNP(ng/dl) | 3547 ± 8492 | 2753 ± 4558 | 4919 ± 12764 | 0.345 |
| Heart Failure Drugs | ||||
| Beta-blockers | 80%(47) | 81%(30) | 77%(17) | 0.750 |
| ACEi/ARBs | 82%(49) | 84%(32) | 77%(17) | 0.512 |
| MRA | 37%(22) | 34%(13) | 41%(9) | 0.600 |
| Ivabradine | 17%(10) | 16%(6) | 18%(4) | 0.849 |
| Loop diuretics | 80%(48) | 76%(29) | 86%(19) | 0.510 |
| Echocardiography | ||||
| Indexed end-diastolic volume(ml/m²) | 99 ± 25 | 91 ± 17 | 104 ± 28 | 0.049 |
| Indexed end-systolic volume(ml/m²) | 71 ± 21 | 64 ± 17 | 75 ± 22 | 0.041 |
| LVEF(%) | 28 ± 6 | 29 ± 7 | 28 ± 6 | 0.660 |
| PAPs(mmHg) | 34 ± 12 | 28 ± 9 | 40 ± 13 | 0.003 |
| LV Lateral lead position | 82%(49) | 89%(34) | 68%(15) | 0.040 |
| CRT-D | 80%(48) | 79%(30) | 82%(18) | 0.118 |
6MWT = Six-minute walking test; ACEi = Angiotensin-converting enzyme inhibitor; ARBs = angiotensin receptor blockers; BMI = Body mass index;; eGFR = estimated glomerular filtration rate; IHM = Ischemic heart disease; LBBB = Left bundle branch block; LVEF = left ventricular ejection fraction; MLWHFQ = Minnesota Living With Heart Failure Questionnaire; MRA = Mineralocorticoid antagonist receptor; NICD = Non-specific intraventricular conduction delay; NYHA = New York Heart Association; PAPs = Pulmonary arterial pressure; RBBB = Right bundle branch block.