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. 2019 Apr 15;9:6082. doi: 10.1038/s41598-019-42625-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROI-based analysis of ¹⁸F-Flortaucipir retention. ¹⁸F-Flortaucipir retention was assessed in composite ROIs consisting of the (A) Lateral temporal cortex (bilaterally), (B) Right lateral temporal cortex, (C) Left lateral temporal cortex, (D) Medial temporal cortex, (E) Lateral parietal cortex, (F) Medial parietal cortex, (G) Frontal cortex, (H) Inferior frontal cortex; and, (I) Occipital cortex. *p < 0.05; **p < 0.01; ****p < 0.0001. Red dots correspond to Aβ-positive individuals according to ¹⁸F-Flutemetamol PET scans, black dots to Aβ-negative individuals and empty circles to individuals with unknown Aβ status. Dotted lines indicates average value + 2 SD for controls.