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. 2019 Apr 15;9:6082. doi: 10.1038/s41598-019-42625-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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³H-Flortaucipir autoradiography in svPPA and C9orf72. Panels (A,B) show representative phosphoimaging results of ³H-Flortaucipir in the (A) temporal and (B) frontal cortex from a patient with svPPA and TDP-43 type C pathology. Image in (C) represents a negative healthy control tissue from temporal cortex. Panels (D,E) show temporal and frontal cortex respectively from a patient with C9orf72-mutation and TDP-43 type B pathology. Images in (F) shows a positive control from AD cortex (superior temporal gyrus). For all image panels the left images show binding with ³H-Flortaucipir and right images remaining binding after addition of 10 µM non-radiolabeled T808. Scale indicates 1 cm.