Table 1.
Demographical, clinical and cognitive data.
| Case | Diagnosis | Demographics (Age, gender, handedness, disease duration, education (years)) | Presenting features | MMSE | Amyloid status (18F-Flutemetamol Berkeley score, cut off >0.693) | CSF-Aβ42/ pTau cut off <8.0 |
|---|---|---|---|---|---|---|
| 1 | L-svPPA | 76, M, Right, 7, 22 | Anomia, impaired single word comprehension, semantic paraphasia | 20 | 0.738 | 1.3 |
| 2 | L-svPPA | 66, M, Right, 8, 13 | Anomia, impaired single word comprehension, sematic paraphasia, logorrhea | 10 | 0.642 | 29.2 |
| 3 | L-svPPA | 64, M, Right, 7, 9 | Anomia, impaired single word comprehension, prosopagnosia | 29 | 0.789 | 5.5 |
| 4 | R-SD | 60, F, Right, 8, 21 | Bipolar II disorder, dysexecutivity, memory loss, mental rigidity and repetitive behaviours, proposagnosia, visual agnosia and anomia | 25 | 0.637 | 23.2 |
| 5 | R-SD | 73, F, Right, 7, 16 | Social inappropriateness, mental rigidity and repetitive behaviours, prosopagnosia, reduced empathy, anomia and impaired single word comprehension | 30 | 0.869 | 4.2 |
| 6 | R-SD | 60, F, Right, 7, 11 | Distractability, social inappropriateness, mental rigidity and repetitive behaviours, prosopagnosia, anomia and impaired single word comprehension | 24 | 0.558 | 18.8 |
| 7 | FTD-C9orf72 | 69, F, Right, 2 14 | Apathy, dysexecutivity, loss of insight, visual hallucinations | 24 | 0.706 | 10.1 |
| 8 | FTD-C9orf72 | 68, M, Right, 2, 10 | Apathy, dysexecutivity, hyperorality, flattening of affect, loss of insight | N/A | N/A | N/A |
| 9 | FTD-C9orf72 | 66, F, Right, 5, N/A | Non-fluent aphasia, reduced empathy, apathy, hyperorality, and paranoid delusions | 21 | N/A | 13.9 |
| 10 | FTD-C9orf72 | 66, F, Right, 3, N/A | Apathy, affective flattening, non-fluent aphasia, motor stereotypies | 20 | N/A | 25.1 |
| 11 | FTD-C9orf72 | 61, F, Right, 3, 12 | Mild executive deficits, irritability, apathy and visual hallucinations | 24 | N/A | N/A |
| 12 | FTD-C9orf72 | 66, F, Right, 4, 9 | Apathy, affective flatting, altered eating habits, loss of insight, paranoid delusions | 21 | N/A | 16.4 |
| Controls | 75 ± 5 yr; 26 F/28 M; N/A; 12 ± 4 yr | — | 29 ± 1 | 26 abnormal 27 normal | 21 abnormal 33 normal |
F – female; FTD – frontotemporal dementia; L – left; M – male; N/A – not available; R – right; SD – semantic dementia; svPPA – semantic variant primary progressive aphasia. Control means are shown ± 1 standard deviation.