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. 2019 Apr 15;5:89. doi: 10.1038/s41420-019-0167-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a miR-4521 expression levels were significantly downregulated in ccRCC cancer tissues compared with paracancerous nontumor renal tissues. b The downregulation efficiency of miR-4521 in tissue samples is shown. Correlations between miR-4521 expression level and the TNM stage (c) and Fuhrman grades (d) of ccRCC are shown, respectively. ccRCC clear cell renal cell carcinoma. *P < 0.05, ****0.0001