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. 2019 Apr 15;5:89. doi: 10.1038/s41420-019-0167-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MTT assays showed that transfection of the miR-4521 mimic can significantly attenuate the proliferation velocity of 786-O (a) and ACHN (b) cells. Representative photographs are shown of migration and invasion assays of 786-O (c) and ACHN (d) cells to determine the tumor suppressor function of miR-4521. e Flow cytometry was performed to reveal that the miR-4521 mimic induced the cell apoptosis of 786-O and ACHN cells. *P values < 0.05, **0.01, ***0.001, ****0.0001