Table 1.

Clinical association of miR-4521 and FAM129A level changes with ccRCC

Characteristics	mRNA and protein expression level change and clinical significance
	No. of patient (55 in total)	Relative miR-4521 levela	P value	Relative FAM129A levela	P value	No. of patient (37 in total)	Relative FAM129A level	P value
Age, years
≤60	34	0.772	0.077	3.476	0674	23	2.834	0.429
>60	21	0.527		3.056		14	3.661
Gender
Male	32	0.774	0.094	3.316	0.999	23	3.846	0.072
Female	23	0.545		3.315		14	1.999
Tumor position
Left kidney	33	0.750	0.195	3.312	0.994	25	3.263	0.742
Right kidney	22	0.571		3.320		12	2.905
Fuhrman grade
I-IIb	33	0.797	0.029	2.522	0.041	20	2.154	0.028
III-IVc	22	0.500		4.505		17	4.315
TNM stage
T1	39	0.716		2.658		22	2.205
T2d	8	0.675	0.017	2.980	0.007	7	3.393	0.024
T3-4e	8	0.499		6.856		8	5.523

ccRCC clear cell renal cell carcinoma

^aRefers to the ratio of miR-4521 and FAM129A mRNA expression level in tumorous tissues divided by that in paracancerous tissue

^bFour patients in Fuhrman grade I-II and six patients in grade II-III were considered together with 23 patients in grade II

^cOne patient in Fuhrman grade IV and one patient in grade III-IV were considered together with 20 patients in grade III

^dOne patient at stage T2-3 was considered together with seven ccRCC patients at stage T2

^eOne patient at stage T4 was considered together with seven ccRCC patients at stage T3