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. 2019 Apr 9;10:683. doi: 10.3389/fmicb.2019.00683

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Copyright © 2019 Girão, Ribeiro, Ribeiro, Azevedo, Pereira, Urbatzka, Leão and Carvalho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of extracts from actinobacterial strains isolated from L. ochroleuca on cellular viability. The effects on the viability of (A) breast carcinoma T-47D and (B) neuroblastoma SH-SY5Y tumor cell lines, and (C) a non-tumor cell line (human brain capillary endothelial cells, hCMEC/D3) are shown after 24 and 48 h of exposure. Only the extracts with significant differences are shown on the graphs for SHSY-5Y and T47D cell lines. All of these extracts were re-tested on the non-cancer cell line (C) for general cytotoxicity. PC and SC indicate positive and solvent controls, respectively. Data are presented as mean ± standard deviation from two independent experiments performed in triplicates each, and significant differences compared to the solvent control are marked with asterisks in the graphs (^∗ = p < 0.05).