Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 15;10:1757. doi: 10.1038/s41467-019-09703-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — CDK12/13 inhibition results in minimal splicing alterations. a Diagrammatic representation (left) and bar plot of splicing events (right) observed in TT-seq analysis of NB cells treated with THZ531 (400 nM) for 2 h. b Scatterplot of intron retention index (IR index) vs. the ratio of exon and intron lengths in log2 scale. Genes with an IR index >1 or ≤1 display intron retention and loss respectively (adjusted p < 0.05, Fisher’s exact test). c Box plot illustrating the length distributions of genes that display intron loss or retention. The center line indicates the median for each data set. d Density plots illustrating the contributions of the proximal (first intron/exon) and distal (last intron/exon) gene regions in calculation of the IR index. Comparison of IR index distribution between proximal and distal intron/exon pairs (p = 0, Kolmogorov-Smirnov test)