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. 2019 Apr 15;9:6020. doi: 10.1038/s41598-019-42292-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Non-stimulated IPF lung fibroblasts show a reduced proliferative response. Proliferation in non-stimulated control (white) and IPF fibroblasts (grey) was measured 72 h using cell count (A). Time course of proliferation in PDGF-stimulated (from control (B) and IPF (C) patients). Proliferation in control (D) and IPF (E) fibroblasts at 72 h following exposure to the indicated PDGF concentrations. Data represents the mean +/− SEM of five individuals. Statistical significance was performed using 1-way analysis of variance (ANOVA) with a Dunnett’s or Tukey’s test for time courses (A–C) where *p < 0.05, **p < 0.01 and ****p < 0.0001. The logEC₅₀ for each individual was determined in GraphPad Prism and comparison between control and IPF groups was performed using a unpaired t-test. The EC₅₀ was calculated from the mean logEC50 values.