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. 2019 Apr 15;9:6020. doi: 10.1038/s41598-019-42292-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome analysis shows differential expression of long intergenic RNA between control and IPF fibroblasts. (A) The differential expression of various classes of genes was examined in 5 control and 5 IPF fibroblasts samples in the presence and absence of TGF-β1 stimulated at 24 h. (B) Table showing the genes with highest fold changes in non-stimulated fibroblasts at 24 h. (C) The differential expression of the two lincRNAs, LINC00960 and LINC01140 was confirmed by qRT-PCR (n = 5). (D) LINC00960 and LINC01140 expression was confirmed by comparison with RNA sequencing data and the epigenetic marks associated with H3K4me3 (active promoters) and H3K27ac (active transcription). (E) Expression of LINC00960 and LINC01140 in the lung biopsies of control (n = 19) and IPF patients (n = 20). Data in (D,E) are the mean +/− SEM and statistical significance was performed using an unpaired t-test where *p < 0.05, **p < 0.01 and ***p < 0.001.