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Directional effect of genetically determined gene expression on disease risk for genes identified in the gene-based analysis of the adjusted breast cancer GWAS
| Direction of effect | Predicted target genes of breast cancer sentinel risk variants |
|---|---|
| Decreased expression associated with decreased risk | IMP3, IRF1, SEMA4A |
| Increased expression associated with decreased risk | LINC00886, MAN2C1, RP11-817O13.8, SIK2, SIN3A |
| Ambiguous | AC034220.3, GSTM2, PPP2R1B |
